IACI Support
for Long Covid
Long Covid Summary
In Long Covid, viral persistence, novel autoimmunity, reactivated viruses, and/or immune cell exhaustion push the body into a debilitating and sometimes progressive state of chronic illness. The body assumes the worst and produces fast fuel from pyruvate and lactic acid for exhausted immune cells. Prolonged amino gluconeogenesis desensitizes metabolic pathways to glucose and/or insulin and feeds unwanted bacteria, neoplasms, and mycoflora in the process. CD8+ T cell exhaustion, peripheral blood mononuclear cell dysfunction, and fungal translocation lead to a wide array of debilitating patient-specific symptoms.
More information below.
Dr. Michael Moran’s Long Covid Support formula combines versatile herbal extracts like Berberine for its neuroprotective and mitoprotective properties with Psoralea fruit for its polymerase inhibiting and hematopoietic properties. The formula incorporates a wide array of essential minerals for mitochondrial support and probiotics that multitask as binders and anti-rheumatics. Dr. Michael has thoughtfully selected each ingredient after years of studying Long Covid in order to support as many patients in as many ways as possible.
Mechanisms of Action
ANTIVIRALS
“IACI” stands for Infection Associated Chronic Illness. There are multiple antivirals in the formula: Psoralea(polymerase inhibitor), Shikonin(CCR5 and Main protease inhibitor), Berberine(neuraminidase inhibitor) which has an IC50 half that of Paxlovid, and Rutin(Main protease inhibitor). Additional antimicrobials include Lysozyme and Lactoferrin(Bovine). Truthfully, each of these ingredients has a myriad other antiviral properties.
ESSENTIAL MINERALS
The building blocks of mitochondria and first line of defense against oxidative stress are essential minerals, all eleven of which, necessary for mitochondrial function, are included in the formula. Notably, the Iron, Magnesium, and Potassium salts of aspartic acid are included because they have been found to facilitate production of oxaloacetate, an important substrate in the Krebs cycle known to combat cellular fatigue.
LUMBROKINASE / BACILLUS SUBTILIS
FERMENTED BLACK SOYBEAN / SCROPHULARIA
Lumbrokinase and Nattokinase are fibrinolytics that, unlike prescription fibrinolytics, do not cause excessive bleeding and treat reservoirs in clots and immune privileged sites. Dan Dou Chi, Fermented Black Soybean, uses Bacillus Subtilis to produce Nattokinase, and happens to be rich in nutrients including protein and immune modulating pigments called anthocyanins(JAK3-inhibitors). Liu Bao-Yi(1842-1901) insisted that Dan Dou Chi be used in Lingering Pathogen formulas for its ability to gently diaphorese without causing damage. Also in IACI Cleanse is Liu Bao-Yi’s other favorite herb for Lingering Pathogens, Xuan Shen(Figwort), commonly used to resolve neoplasm in lymphoid tissue.
TAURINE / BERBERINE / INOSITOL / RUTIN
Taurine functions somewhat like a mineral within the body and mitochondria while strengthening organelle membranes. Rutin and Taurine are antiarrhythmic and cardioprotective. Berberine activates AMPK, increases ATP output by at least 20%, reduces lactic acid production, inhibits amino gluconeogenesis, and kills sulfur producing bacteria in the gut. Berberine, Rutin, and Taurine reduce reactive oxygen species by increasing catalase, glutathione and superoxide dismutase. Berberine, Inositol, Taurine, and Rutin improve glucose metabolism while inhibiting or reversing mitochondrial fragmentation. Berberine, Rutin and Taurine are mast cell stabilizers, potently neuroprotective, and protect metabolic tissue from oxidative stress.
CODONOPSIS / PINELLIA / ATRACTYLODES
PORIA / JUJUBE / REED RHIZOME
The herbs(ginseng, pinellia, poria, chinese date, fermented black soybean, atractylodes, and reed rhizome) make the formula that of a Lingering Pathogen formula in Traditional Chinese Medicine which is thought to facilitate the resolve of persistent virus through the "channels"(bowels, urine, and sweat). Lingering pathogens are a big part of Chinese medicine, documented as early as 2,000 B.C.
PRE/PROBIOTICS / ENZYMES / IMMUNE FACTORS
Of the probiotics, Saccharomyces Boulardii is a competitive antifungal and binder, Bacillus Coagulans regulates INF-y TNF-a and IL-6, Lactobacillus Rhamnosus is a competitive probiotic that eradicates B. Wadsworthia(sulfur producing bacteria missed by Berberine), Bacillus Subtilis upregulates enzymes that can manage fungal translocation seen in Long Covid. Colostrum, lactoferrin, lysozyme, and olive leaf work with the probiotics to develop a healthy intestinal microflora. The formula includes dense Aloe solids as prebiotics to promote bulk, binding, and motility.
CHOLINERGICS
Huperzine A, Berberine, Zinc, Copper, Ginger, and Magnesium all increase acetylcholine and/or cholinergic activity to improve memory and cognition.
Concerns and Hopes
Cures, in a broad sense, do not exist nor are they what marketing companies claim them to be. "Cures" enable aspects of capitalist and eugenic culture designed to make money only to leave others behind as seen in the global response to COVID-19.
More and more research is warning of progressive neurodegenerative disease after COVID-19. If you haven't already, consider applying for disability subsidies in your country if you qualify and/or if your ability to provide for yourself has changed or become unpredictable because of COVID-19.
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Metabolic / Mitochondrial / Redox Imbalance:
↓arginine, ↑ornithine/citrulline ratio
(↑ammonia, ↑lactate, ↓NO)
(Redox State Imbalance, ↓NAD+)
(Warburg Effect)
↑amino/hepatic gluconeogenisis
(glucose resistance, dysregulated glucose-alanine cycle, →muscle breakdown)
HHV / EBV / HERV-W Activation:
↑kynurenic acid ↑syncytin-1 ↑DUX4 ↑fibronectin (↑clotting, ↑neoplasms)
All underlined text above links to correlating citations.
*Metabolome findings based on https://www.medrxiv.org/content/10.1101/2023.05.03.23289456v1.full.pdf
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